TRPM7 and EEF2

Number of citations of the paper that reports this interaction (PubMedID 14594813)
61

Data Source:
HPRD (in vitro)

		TRPM7	EEF2
Description		transient receptor potential cation channel subfamily M member 7	eukaryotic translation elongation factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Secretory Granule Lumen Polysomal Ribosome Membrane Raft Synapse Extracellular Exosome Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Actin Binding Cation Channel Activity Calcium Channel Activity ATP Binding Myosin Binding Metal Ion Binding Protein Serine Kinase Activity	P53 Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding 5S RRNA Binding Protein Kinase Binding Ribosome Binding Cadherin Binding Actin Filament Binding
	Biological Process	Calcium Ion Transport Cellular Magnesium Ion Homeostasis Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Protein Autophosphorylation Protein Tetramerization Necroptotic Process Calcium Ion Transmembrane Transport Divalent Inorganic Cation Homeostasis Cation Transmembrane Transport	Hematopoietic Progenitor Cell Differentiation Response To Ischemia Skeletal Muscle Contraction Translational Elongation Aging Response To Xenobiotic Stimulus Glial Cell Proliferation Response To Estradiol Response To Endoplasmic Reticulum Stress Skeletal Muscle Cell Differentiation Response To Hydrogen Peroxide Response To Ethanol Positive Regulation Of Translation Response To Folic Acid Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Cytoplasmic Translation
Pathways		TRP channels	Peptide chain elongation Peptide chain elongation Uptake and function of diphtheria toxin Synthesis of diphthamide-EEF2 Synthesis of diphthamide-EEF2 Neutrophil degranulation Protein methylation
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester 1,4-Dithiothreitol	Adenosine-5-Diphosphoribose Diphthamide Guanosine-5'-Diphosphate N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Esketamine Moxetumomab Pasudotox
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Calcium levels ( 29403010) Chronic obstructive pulmonary disease ( 30804561) Electrocardiographic traits (multivariate) ( 32602732) Household income (MTAG) ( 31844048) Pulse pressure ( 27841878) QT interval ( 24952745) Systolic blood pressure ( 27841878)
Interacting Genes		9 interacting genes: ANXA1 EEF2 H3-4 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6	22 interacting genes: CCT2 CDKN2A CREBBP DISC1 DUX4 EEF2K EP300 ESR1 HNRNPD LINC01554 MAPKAPK3 MLH1 NDRG1 PPM1A PPP2CA PPP2R1A PPP2R1B PTEN SUMO2 TP53 TRPM7 UCHL5
Entrez ID		54822	1938
HPRD ID		10418	00561
Ensembl ID		ENSG00000092439	ENSG00000167658
Uniprot IDs		A0A024R5V1 H0YLN8 Q96QT4	A0A384N6H1 P13639
PDB IDs			4V6X 6D9J 6Z6M 6Z6N
Enriched GO Terms of Interacting Partners?
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