EPDR1 and IGFBP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EPDR1	IGFBP6
Description		ependymin related 1	insulin like growth factor binding protein 6
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GO Annotations	Cellular Component	Extracellular Region Lysosome Lysosomal Lumen	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex
	Molecular Function	Calcium Ion Binding Protein Binding Phospholipid Binding Identical Protein Binding Ganglioside GM1 Binding	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding
	Biological Process	Cell-matrix Adhesion Myofibroblast Contraction	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Dupuytren's disease ( 28886342 21732829) Glaucoma (primary angle closure) ( 27064256) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lateral ventricle volume ( 31530798) Lumbar spine bone mineral density ( 29499414) Rosacea symptom severity ( 29771307)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)
Interacting Genes		13 interacting genes: ADAMTSL4 EHMT2 HOXA1 IGFBP6 KRT31 KRT34 KRTAP10-8 KRTAP13-2 KRTAP4-11 PM20D2 TNS2 TRIP6 UBQLN4	40 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DDX10 EFEMP1 EFEMP2 ENKD1 EPDR1 ERBB3 GAS8 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Entrez ID		54749	3489
HPRD ID		16865	00902
Ensembl ID		ENSG00000086289	ENSG00000167779
Uniprot IDs		Q96J80 Q9UM22	P24592
PDB IDs		6E7O 6E8N 6JLD	1RMJ
Enriched GO Terms of Interacting Partners?
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