LZTFL1 and TRIM68

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LZTFL1	TRIM68
Description		leucine zipper transcription factor like 1	tripartite motif containing 68
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Androgen Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Localization To Ciliary Membrane	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Regulation Of Androgen Receptor Signaling Pathway
Pathways		BBSome-mediated cargo-targeting to cilium	Interferon gamma signaling
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) COVID-19 (critical illness vs population) ( 33307546) Eosinophil percentage of white cells ( 32888494) Methadone dose in opioid dependence ( 28115739) Multiple sclerosis ( 31604244) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)	Malaria ( 31844061) Mean corpuscular hemoglobin ( 28548082) Mean corpuscular hemoglobin concentration ( 28548082) Mean corpuscular volume ( 28548082) Red blood cell count ( 28548082) White blood cell count ( 28548082)
Interacting Genes		10 interacting genes: EHHADH FZD5 MOB1A NTAQ1 PELI2 PICK1 PSMA1 PSMB1 SDCBP TRIM68	14 interacting genes: DISC1 INCA1 KRTAP13-2 KRTAP13-3 LNX1 LZTFL1 NUDT16L1 POLR2G REL TCF4 TEPSIN UBE2D3 UBE2U ZBTB42
Entrez ID		54585	55128
HPRD ID		07586	11507
Ensembl ID		ENSG00000163818	ENSG00000167333
Uniprot IDs		Q9NQ48	Q6AZZ1
PDB IDs
Enriched GO Terms of Interacting Partners?
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