POLD1 and TREX2

Number of citations of the paper that reports this interaction (PubMedID 12806015)
9

Data Source:
HPRD (in vitro)

		POLD1	TREX2
Description		DNA polymerase delta 1, catalytic subunit	three prime repair exonuclease 2
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Membrane Aggresome Delta DNA Polymerase Complex	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5'-exodeoxyribonuclease Activity Enzyme Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Magnesium Ion Binding Nucleic Acid Binding Protein Binding 3'-5'-exodeoxyribonuclease Activity Exodeoxyribonuclease III Activity Protein Homodimerization Activity
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-dependent DNA Replication DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling Response To UV Cellular Response To UV DNA Replication Proofreading Fatty Acid Homeostasis Error-free Translesion Synthesis DNA Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Catabolic Process, Exonucleolytic DNA Metabolic Process DNA Repair
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Cytosolic iron-sulfur cluster assembly Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)
Interacting Genes		23 interacting genes: ADAMTSL4 ASXL1 ATR CCND3 CCNE1 CDK2 CDK4 CEP126 CHGB GINS4 LASP1 MCPH1 PCNA POLA1 POLD2 POLD3 POLD4 SUMO2 TREX2 TRIM55 WRNIP1 XRCC5 YPEL3	4 interacting genes: ATF4 MESD POLD1 UBE2N
Entrez ID		5424	11219
HPRD ID		08882	02299
Ensembl ID		ENSG00000062822	ENSG00000183479
Uniprot IDs		A0A024R4F4 A0A087WYJ2 M0R2B7 P28340 Q308M6 Q59FA0	Q9BQ50
PDB IDs		6S1M 6S1N 6S1O 6TNY 6TNZ	1Y97
Enriched GO Terms of Interacting Partners?
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