SNTG2 and HACE1

Number of citations of the paper that reports this interaction (PubMedID 27404360)
14

Data Source:
BioGRID (enzymatic study, pull down)

		SNTG2	HACE1
Description		syntrophin gamma 2	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Sarcolemma	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Nuclear Body Golgi Cisterna Membrane
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding PDZ Domain Binding Neuroligin Family Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Central Nervous System Development	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Golgi Organization Cell Cycle Protein Ubiquitination Rac Protein Signal Transduction Regulation Of Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Membrane Fusion Protein K48-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Calcific aortic valve stenosis ( 32141789) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hypothyroidism ( 27182965) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Age at voice drop ( 27182965) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Feeling guilty ( 29500382) Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29617998) Major depressive disorder ( 27479909) Menarche (age at onset) ( 19448622 27182965) Multiple sclerosis ( 23412934) Neuroblastoma ( 22941191) Obsessive-compulsive disorder ( 22889921) Resistant hypertension ( 31545351) Schizophrenia ( 28991256) Sporadic neuroblastoma ( 28545128) Thyroid stimulating hormone levels ( 17903292) Type 2 diabetes ( 31049640) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		12 interacting genes: ADGRB1 BET1 DMD DTNA DTNB HACE1 MIPOL1 MPP3 PALS1 RPS6KA1 SCN5A VCPIP1	9 interacting genes: MTDH OPTN PAK1 PLXNA2 RAB4A RAC1 SNTG2 UBE2D2 UBE2L3
Entrez ID		54221	57531
HPRD ID		16374	17086
Ensembl ID		ENSG00000172554	ENSG00000085382
Uniprot IDs		Q9NY99	Q8IYU2
PDB IDs
Enriched GO Terms of Interacting Partners?
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