CLIC5 and IQGAP1

Number of citations of the paper that reports this interaction (PubMedID 10793131)
45

Data Source:
HPRD (in vitro)

		CLIC5	IQGAP1
Description		chloride intracellular channel 5	IQ motif containing GTPase activating protein 1
Image
GO Annotations	Cellular Component	Golgi Apparatus Microtubule Organizing Center Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Stereocilium Bundle Chloride Channel Complex Extracellular Exosome	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Microtubule Cytoskeleton Axon Growth Cone Midbody Secretory Granule Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Membrane Raft Extracellular Exosome
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding	MAP-kinase Scaffold Activity GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Cadherin Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Molecular Adaptor Activity
	Biological Process	Glutathione Metabolic Process Chloride Transport Female Pregnancy Visual Perception Sensory Perception Of Sound Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Response To Stimulus	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Cell Migration Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Catalytic Activity Regulation Of GTPase Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Focal Adhesion Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Glomerular Visceral Epithelial Cell Development Positive Regulation Of Dendrite Development Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Localization Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Neuron Projection Extension Response To Angiotensin
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Artenimol
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576 29875488) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Coronary artery disease in type 1 diabetes ( 32077919) Gout (normal type) ( 32238385) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Itch intensity from mosquito bite ( 28199695) LDL cholesterol levels in HIV infection ( 33109212) Mosquito bite size ( 28199695) Periodontal microbiota ( 22699663)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Chronic postoperative pain ( 31903573) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 30598549) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Male-pattern baldness ( 28196072) Multiple sclerosis ( 24076602) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 32868391) White blood cell count (basophil) ( 27863252)
Interacting Genes		9 interacting genes: ACTA1 ACTN1 EZR GSN IQGAP1 LAMTOR5 PTK7 SRPK1 TPRN	39 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CLIC5 CLIP1 CREBBP CTNNB1 CYBB DUX4 EGFR EZR GRIA4 ILF2 KDR LBX1 MAPK1 MEI4 MEN1 MEOX2 MYL1 NPHS1 OTX2 PDLIM7 PKNOX2 PRKACA PTPRM RAC1 S100B STAU1 SUMO2 TEPSIN TSG101 UBE2I VASP YWHAQ
Entrez ID		53405	8826
HPRD ID		06292	04541
Ensembl ID		ENSG00000112782	ENSG00000140575
Uniprot IDs		Q49AE1 Q53G01 Q9NZA1	A0A024RC65 P46940
PDB IDs		6Y2H	1X0H 2RR8 3FAY 3I6X 5L0O
Enriched GO Terms of Interacting Partners?
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