NUP54 and DCTN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NUP54	DCTN3
Description		nucleoporin 54	dynactin subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Membrane Nuclear Pore Central Transport Channel	Kinetochore Nucleolus Centrosome Spindle Cytosol Dynactin Complex Microtubule Midbody Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-containing Complex Binding	Structural Molecule Activity Protein Binding
	Biological Process	Protein Targeting NLS-bearing Protein Import Into Nucleus Nuclear Pore Organization Protein Localization To Nuclear Inner Membrane Regulation Of Protein Import Into Nucleus MRNA Transport	Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Cytokinesis
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Hippocampal volume ( 29274321)
Interacting Genes		50 interacting genes: AGR2 AP1B1 AP2B1 APC BPIFA1 C14orf119 C1orf109 C21orf91 CCDC85B CCHCR1 CDC23 CENPH DCTN3 DGCR6 EFHC1 EIF3F EXOC1 EXOC8 GOLIM4 HAUS1 HAUS8 HGS HOMER1 IFT20 KPNA1 KPNB1 KRT15 KRT27 KRT33B NFKBID NR3C1 NUP62 NUTF2 OGT OIP5 PKNOX2 SEPTIN11 SMYD3 SOHLH1 SPG21 SSR1 TACC3 TCHP TEKT1 TEX12 THAP6 TPM3 TRIM54 VPS37C ZWINT	13 interacting genes: ATXN1 CCL19 CCL21 DCTN1 GSK3B KRT34 NUP54 PBX2 PITX1 TRIM55 TRIP13 USHBP1 VPS37C
Entrez ID		53371	11258
HPRD ID		06352	06303
Ensembl ID		ENSG00000138750	ENSG00000137100
Uniprot IDs		Q7Z3B4	O75935 X6RLR1
PDB IDs		4JNU 4JNV 4JO7 4JO9 5IJN 5IJO
Enriched GO Terms of Interacting Partners?
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