PLCG1 and DDR1

  • Number of citations of the paper that reports this interaction (PubMedID 10783152)
  • 7
  • Data Source:
  • HPRD (in vivo, in vitro)

PLCG1

DDR1

Description phospholipase C gamma 1 discoidin domain receptor tyrosine kinase 1
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Age-related macular degeneration ( 23455636)
  • Arterial stiffness index ( 31235810)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • HIV-1 control ( 20041166)
  • Lung cancer ( 28604730)
  • Lung cancer in ever smokers ( 28604730)
  • Malaria ( 31844061)
  • Microalbuminuria in type 1 diabetes ( 31537649)
  • Response to hepatitis B vaccine ( 29534301)
  • Rosacea symptom severity ( 29771307)
  • Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848)
  • Schizophrenia ( 30285260)
  • Serum alkaline phosphatase levels ( 33547301)
  • Smoking initiation (ever regular vs never regular) ( 30679032)
  • Takayasu arteritis ( 25604533)
  • Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
  • Ulcerative colitis ( 20848476)
  • Waist-hip index ( 34021172)
  • Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes 111 interacting genes: ABL1 AGAP2 AGTR1 AKT1 ALK AR ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MAPT MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PRMT8 PTK2 PTPN11 PTPRJ RACK1 RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRIM14 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70 20 interacting genes: BEND5 BRD2 COL11A1 COL2A1 COL3A1 COL5A2 ERBB2 FRS2 MAPK6 NCK2 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR UBQLN2
Entrez ID 5335 780
HPRD ID 01398 02678
Ensembl ID ENSG00000124181 ENSG00000204580
Uniprot IDs P19174 Q4LE43 Q9UFY1 A0A024RCJ0 A0A024RCL1 A0A024RCQ1 A0A0A0MSX3 Q08345 Q96T61 Q96T62
PDB IDs 1HSQ 2HSP 4EY0 4FBN 3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX 6BRJ 6BSD 6FEW 6FEX 6FIL 6FIN 6FIO 6FIQ 6GWR 6HP9 6Y23 7BCM 7BE6
Enriched GO Terms of Interacting Partners?
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