PKP2 and ARMC8

Number of citations of the paper that reports this interaction (PubMedID 30482882)
3

Data Source:
BioGRID (two hybrid)

		PKP2	ARMC8
Description		plakophilin 2	armadillo repeat containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome Messenger Ribonucleoprotein Complex	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol GID Complex Specific Granule Lumen Intracellular Membrane-bounded Organelle Tertiary Granule Lumen
	Molecular Function	Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Transmembrane Transporter Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Protein Binding
	Biological Process	Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Heart Development Positive Regulation Of Sodium Ion Transport Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Keratinization Formation of the cornified envelope	Neutrophil degranulation
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 32201043 27182965) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)	Body shape index ( 34021172) Mean spheric corpuscular volume ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		45 interacting genes: ACTN3 AKAP9 ARMC8 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTNNB1 DDX11 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 ITPR2 JUP KDM5A KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 ROPN1 SINHCAF SMAD9 SPTA1 TEKT4 YWHAG	11 interacting genes: CIB3 CTNNA1 GID8 MAEA PKP1 PKP2 PKP4 STX6 TCF12 TNNT1 ZMYND12
Entrez ID		5318	25852
HPRD ID		04177	09992
Ensembl ID		ENSG00000057294	ENSG00000114098
Uniprot IDs		Q99959	B7Z637 Q8IUR7
PDB IDs		3TT9
Enriched GO Terms of Interacting Partners?
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