PIK3CA and STK11

  • Number of citations of the paper that reports this interaction (PubMedID 28205554)
  • 52
  • Data Source:
  • BioGRID (fluorescent resonance energy transfer)

PIK3CA

STK11

Description phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha serine/threonine kinase 11
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Asthma (childhood onset) ( 31036433)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Crohn's disease ( 28067908)
  • Distal/Left-sided colorectal cancer ( 33632709)
  • Inflammatory bowel disease ( 28067908)
  • Lymphocyte counts ( 32888494 27863252)
  • Lymphocyte percentage of white cells ( 32888494)
  • Neutrophil percentage of white cells ( 32888494)
  • PR interval ( 32439900)
  • Psychosis in Alzheimer's disease ( 22005930)
Interacting Genes 78 interacting genes: ACOT8 ADAP1 AKT1 ALCAM AMBP APLP2 APPL1 ARAF ATP5IF1 ATR BEX1 BEX2 CCND2 CRIP1 CSF1R CYTH2 CYTH3 DDX5 DNAJB6 EGFR FANCC FASLG FBP2 FTL GABRB1 GALNT12 GLIS2 GNAQ GRIN2B HRAS IL13RA2 IL24 IL3 IRS2 IRS4 ITIH1 KRAS LCK LYPLA1 MAP2K1 MAP3K9 MRAS MYC NEDD4L NEDD9 NRAS PDGFRA PDGFRB PDK1 PIK3R1 PIK3R3 PRKCD PRKCI PSMC3IP PTPN11 RASD2 RASGRP3 RELA RHOC RPS20 RPS6KB1 SFRP4 SGK1 SH3KBP1 SMAD2 SMAD3 SNX9 SQSTM1 STAT1 STK11 THRSP TICAM1 TMOD1 TNFSF13 TRA2B UFD1 UMPS VARS2 140 interacting genes: ABCB5 ADIPOR1 AKT1 ALDOB ANP32B APP ARAF ARG2 ARNT ATM AURKA BAP1 BCAS3 BECN1 BRAF CAB39 CALM2 CBLC CCDC180 CCND2 CCNE1 CD44 CDC14B CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFL2 CRY2 CTSB CYLC2 CYP17A1 D2HGDH DACH1 EEF1A2 EPHA2 ERBB2 ERLEC1 ETV4 FAIM2 FAM98B FBP1 FBP2 FGFR4 FZR1 GLIS2 GNPDA1 GRM1 HERC2 HGF HIF1A HRAS IGFBP3 KAT2A KDELR2 KLK7 LATS2 LEF1 LYPD3 MADCAM1 MAP2K1 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MAPK3 MAPRE1 MARK1 MARK2 MARK4 MDM2 MET MOB4 MOCS2 MT-ND2 MYC NANS NAT2 NF2 PARD3 PDGFRA PDXP PHF23 PIK3CA PLD3 PPP2CB PPP6R1 PRKAA1 PRKAA2 PRKACA PRSS50 PTEN RASA1 RASSF1 RHOBTB2 RPS6KA3 RPS6KA5 RPS6KB1 S100A14 SEPTIN9 SERPINB5 SH3GL1 SIK1 SIRT1 SMAD1 SMARCA4 SNRK SOX4 SPDEF ST14 STK11IP STK24 STRADA STRADB STX17 TBC1D23 TDRD7 TEAD2 TERT THOP1 THRSP TNFRSF1A TNIP2 TP53 TRIM25 TRMO TSG101 TUBA1A TUBB4A UBE2D2 VPS72 WT1 XPA YWHAG ZNF189 ZNF195 ZNF510
Entrez ID 5290 6794
HPRD ID 01382 03740
Ensembl ID ENSG00000121879 ENSG00000118046
Uniprot IDs P42336 Q4LE51 A0A0S2Z4D1 Q15831
PDB IDs 2ENQ 2RD0 3HHM 3HIZ 3ZIM 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4TUU 4TV3 4WAF 4YKN 4ZOP 5DXH 5DXT 5FI4 5ITD 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBR 5UK8 5UKJ 5UL1 5XGH 5XGI 5XGJ 6GVF 6GVG 6GVH 6GVI 6NCT 6OAC 6PYS 6VO7 7K6M 7K6N 7K6O 7K71 2WTK 4ZDR 5WXN
Enriched GO Terms of Interacting Partners?
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