SERPINB5 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		SERPINB5	PALB2
Description		serpin family B member 5	partner and localizer of BRCA2
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm	Nucleoplasm Protein-containing Complex
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	DNA Binding Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Regulation Of Epithelial Cell Proliferation Prostate Gland Morphogenesis	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs		S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145)	Bipolar disorder ( 17554300)
Interacting Genes		26 interacting genes: AKT1 ATIC BASP1 BCAR3 CASP8 COL1A2 EEF1A1 ESR1 GOLGA4 GSTO1 HDAC1 HSP90AA1 HSP90AB1 HSPA5 KRAS LRRFIP1 MDH1 MT1H PALB2 PPIF SMAD4 STK11 TBP TKT UCHL5 XRCC3	32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		5268	79728
HPRD ID		01111	07966
Ensembl ID		ENSG00000206075	ENSG00000083093
Uniprot IDs		A0A024R2B6 P36952	H3BN63 Q86YC2
PDB IDs		1WZ9 1XQG 1XQJ 1XU8	2W18 3EU7
Enriched GO Terms of Interacting Partners?
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