PEPD and BBS1

		PEPD	BBS1
Description		peptidase D	Bardet-Biedl syndrome 1
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GO Annotations	Cellular Component	Extracellular Exosome	Centrosome Cytosol Axoneme BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Manganese Ion Binding Metalloaminopeptidase Activity Proline Dipeptidase Activity	Patched Binding Smoothened Binding Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Proteolysis Cellular Amino Acid Metabolic Process Collagen Catabolic Process	Visual Perception Sensory Perception Of Smell Golgi To Plasma Membrane Protein Transport Photoreceptor Cell Maintenance Response To Stimulus Cilium Assembly Protein Localization To Cilium Non-motile Cilium Assembly
Pathways			BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Adiponectin levels ( 22479202 31178129 24105470) Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Birth weight ( 27680694) Bitter alcoholic beverage consumption ( 31046077) Body fat percentage and HDL-C (pairwise) ( 33619380) Body fat percentage and triglycerides (pairwise) ( 33619380) Body shape index ( 34021172) Creatine kinase levels ( 29403010) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 33402679 34059833) Fusiform gyrus volume ( 31530798) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 32203549 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lead levels in blood ( 25820613) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Reticulocyte count ( 32888494) Schizophrenia ( 26198764) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549 28334899 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 30275531) Type 2 diabetes ( 30297969 32499647 22158537 30718926 28869590) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500) White blood cell count ( 32888494)	Bipolar disorder ( 21926972) Height ( 28552196)
Interacting Genes		5 interacting genes: ATXN1 BBS1 SPP1 TERF1 USP7	19 interacting genes: ACTN3 ATP6AP2 BAD BAK1 BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 PARK7 PAX2 PEPD POLR2G TSPAN7
Entrez ID		5184	582
HPRD ID		01358	01950
Ensembl ID		ENSG00000124299	ENSG00000174483
Uniprot IDs		A0A140VJR2 P12955	Q8NFJ9
PDB IDs		2IW2 2OKN 5M4G 5M4J 5M4L 5M4Q 5MBY 5MBZ 5MC0 5MC1 5MC2 5MC3 5MC4 5MC5 6H2P 6H2Q 6QSB 6QSC 6SRE 6SRF 6SRG	6XT9
Enriched GO Terms of Interacting Partners?
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