GHRL and ACE2

Number of citations of the paper that reports this interaction (PubMedID 11815627)
476

Data Source:
HPRD (in vitro)

		GHRL	ACE2
Description		ghrelin and obestatin prepropeptide	angiotensin converting enzyme 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Brush Border Membrane Membrane Raft Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding	Virus Receptor Activity Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation Glucose Metabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Gastric Emptying Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Growth Rate Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Apoptotic Process Cortisol Secretion Positive Regulation Of MAPK Cascade Response To Estrogen Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Development Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Positive Regulation Of Adipose Tissue Development Positive Regulation Of Gastric Mucosal Blood Circulation Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation	Regulation Of Cytokine Production Angiotensin Maturation Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Tryptophan Transport Regulation Of Vasoconstriction Regulation Of Transmembrane Transporter Activity Regulation Of Cell Population Proliferation Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Regulation Of Inflammatory Response Positive Regulation Of Amino Acid Transport Positive Regulation Of Cardiac Muscle Contraction Blood Vessel Diameter Maintenance Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of L-proline Import Across Plasma Membrane Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Metabolism of Angiotensinogen to Angiotensins Attachment and Entry Potential therapeutics for SARS Attachment and Entry Attachment and Entry
Drugs			Chloroquine Hydroxychloroquine SPP1148 N-(2-Aminoethyl)-1-aziridineethanamine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) ghrelin levels ( 33852427)
Interacting Genes		11 interacting genes: ACE2 AGRP CNTN4 GHRHR GHSR LEP MLNR NPY SIL1 UBQLN1 UBQLN2	25 interacting genes: AGT CALM1 CDSN DEFA5 DLEU2 GHRL MAST1 MAST2 NTS PARD3 PDZK1 PTPN3 SCRIB SHANK1 SHANK2 SHANK3 SHROOM2 SLC6A19 SLC9A3R1 SLC9A3R2 SNX17 SNX27 TAMALIN TMPRSS11A TMPRSS11D
Entrez ID		51738	59272
HPRD ID		05638	02274
Ensembl ID		ENSG00000157017	ENSG00000130234
Uniprot IDs		Q9UBU3	Q9BYF1
PDB IDs		1P7X 6H3E	1R42 1R4L 1XJP 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL 6ACG 6ACJ 6ACK 6CS2 6LZG 6M0J 6M17 6M18 6M1D 6VW1 7A91 7A92 7A94 7A95 7A96 7A97 7A98 7BH9 7CT5 7DF4 7DMU 7JVO 7KJ2 7KJ3 7KJ4 7KMB 7KMS 7KMZ 7KNB 7KNE 7KNH 7KNI 7L0N 7L7F
Enriched GO Terms of Interacting Partners?
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