CDK5RAP1 and NKX2-2

		CDK5RAP1	NKX2-2
Description		CDK5 regulatory subunit associated protein 1	NK2 homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Mitochondrion Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Kinase Binding N6-isopentenyladenosine Methylthiotransferase Activity Protein-containing Complex Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Brain Development TRNA Methylthiolation Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Translational Fidelity Positive Regulation Of Mitochondrial Translation Mitochondrial TRNA Modification	Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Brain Development Response To Glucose Positive Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Cell Differentiation Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Ventral Spinal Cord Interneuron Fate Determination
Pathways			Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Hip circumference adjusted for BMI ( 34021172 25673412) Mean corpuscular volume ( 32888494)	Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: CDK5 CDK5R1 EXOSC3 EXOSC5 KIZ NKX2-2 PPP1R16B	7 interacting genes: CDK5RAP1 DLGAP4 KIZ OLIG2 RASSF2 RECQL SPEF1
Entrez ID		51654	4821
HPRD ID		12189	05213
Ensembl ID		ENSG00000101391	ENSG00000125820
Uniprot IDs		A0A0S2Z592 A0A0S2Z5J9 Q53H36 Q96SZ6	O95096
PDB IDs
Enriched GO Terms of Interacting Partners?
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