NKX2-2 and RECQL

		NKX2-2	RECQL
Description		NK2 homeobox 2	RecQ like helicase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Chromosome Cytoplasm Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	DNA Binding DNA Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity ATP Hydrolysis Activity ATP-dependent DNA/DNA Annealing Activity 3'-5' DNA Helicase Activity
	Biological Process	Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Brain Development Response To Glucose Positive Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Cell Differentiation Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Ventral Spinal Cord Interneuron Fate Determination	Double-strand Break Repair Via Homologous Recombination DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725) Refractive error ( 32231278)	Blood protein levels ( 30072576)
Interacting Genes		7 interacting genes: CDK5RAP1 DLGAP4 KIZ OLIG2 RASSF2 RECQL SPEF1	7 interacting genes: KPNA2 KPNA4 MARK3 NKX2-2 PLEKHA5 RPA1 UBC
Entrez ID		4821	5965
HPRD ID		05213	02762
Ensembl ID		ENSG00000125820	ENSG00000004700
Uniprot IDs		O95096	A0A024RAV2 P46063
PDB IDs			2V1X 2WWY 4U7D 6JTZ
Enriched GO Terms of Interacting Partners?
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