CHMP3 and IGFBP7

Number of citations of the paper that reports this interaction (PubMedID 11549700)
10

Data Source:
HPRD (in vivo)

		CHMP3	IGFBP7
Description		charged multivesicular body protein 3	insulin like growth factor binding protein 7
Image			No pdb structure
GO Annotations	Cellular Component	ESCRT III Complex Early Endosome Late Endosome Multivesicular Body Cytosol Plasma Membrane Midbody Cytoplasmic Vesicle Late Endosome Membrane Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylcholine Binding Ubiquitin-specific Protease Binding	Extracellular Matrix Structural Constituent Protein Binding Insulin-like Growth Factor Binding
	Biological Process	Apoptotic Process Nucleus Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Macroautophagy Positive Regulation Of Cytokinesis Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Regulation Of Endosome Size Protein Polymerization Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Negative Regulation Of Viral Release From Host Cell Positive Regulation Of Viral Release From Host Cell Regulation Of Exosomal Secretion Regulation Of Early Endosome To Late Endosome Transport	Regulation Of Cell Growth Cell Adhesion Embryo Implantation Negative Regulation Of Cell Population Proliferation Response To Heat Regulation Of Signal Transduction Response To Retinoic Acid Cellular Response To Hormone Stimulus Regulation Of Steroid Biosynthetic Process Response To Cortisol
Pathways		Budding and maturation of HIV virion Macroautophagy Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Insulin pork
Diseases
GWAS		Adult body size ( 32376654) Glomerular filtration rate in chronic kidney disease ( 26420894) Nicotine dependence symptom count ( 25555482)	Age-related macular degeneration ( 21909106) Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576 29875488 28240269) Brain volume in infants (grey matter) ( 28763065) Congenital heart disease (maternal effect) ( 28468790) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 28869591) Hyperemesis gravidarum ( 29563502) Schizophrenia x sex interaction ( 34099189) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		13 interacting genes: APP CHMP2A CHMP2B CHMP4A CHMP4B FBXO7 IGFBP7 RAB11A SMAD1 SMAD5 STAMBP TNPO3 VAV2	11 interacting genes: CCL21 CCL5 CHMP3 CXCL10 IGF1 IGF2 INHBA INS RBBP8 SDC1 VEGFA
Entrez ID		51652	3490
HPRD ID		15650	04183
Ensembl ID		ENSG00000115561	ENSG00000163453
Uniprot IDs		Q9Y3E7	Q16270
PDB IDs		2GD5 2XZE 3FRT 3FRV
Enriched GO Terms of Interacting Partners?
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