GSKIP and EVL

		GSKIP	EVL
Description		GSK3B interacting protein	Enah/Vasp-like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Beta-catenin Binding Kinase Regulator Activity Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways			Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases
GWAS		Conotruncal heart defects (inherited effects) ( 28468790)	Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		4 interacting genes: EVL EXT2 GSK3A PEX19	45 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP ATG2B BDKRB1 BEGAIN C14orf132 CKB CRKL DNMBP ENAH F11R FXR1 FXR2 FYB1 FYN GSKIP HCK HTT KRT17 KRT34 LRP1B LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		51527	51466
HPRD ID		16601	10942
Ensembl ID		ENSG00000100744	ENSG00000196405
Uniprot IDs		A0A024R6P6 Q9P0R6	A0A024R6K5 Q9UI08
PDB IDs		1SGO
Enriched GO Terms of Interacting Partners?
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