TLR8 and UTP18

		TLR8	UTP18
Description		toll like receptor 8	UTP18 small subunit processome component
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Endolysosome Membrane	Nucleus Nucleoplasm Nucleolus Nuclear Membrane Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding NAD+ Nucleosidase Activity Transmembrane Signaling Receptor Activity Signaling Receptor Activity Pattern Recognition Receptor Activity	RNA Binding
	Biological Process	Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Immunoglobulin Mediated Immune Response Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 8 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Cellular Response To Mechanical Stimulus	RRNA Processing
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Imiquimod Resiquimod
Diseases
GWAS		Celiac disease ( 20190752)	Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Menarche (age at onset) ( 27182965) Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: BTK MYD88 UTP18	10 interacting genes: CSNK2A1 ERBB2 HDAC5 KCNJ2 MBTD1 OGT PRDM1 RSAD1 TLR8 TXK
Entrez ID		51311	51096
HPRD ID		02296	10825
Ensembl ID		ENSG00000101916	ENSG00000011260
Uniprot IDs		Q9NR97	Q9Y5J1
PDB IDs		3W3G 3W3J 3W3K 3W3L 3W3M 3W3N 3WN4 4QBZ 4QC0 4R07 4R08 4R09 4R0A 4R6A 5AWA 5AWB 5AWC 5AWD 5AZ5 5HDH 5WYX 5WYZ 5Z14 5Z15 6KYA 6TY5 6V9U 6WML 6ZJZ
Enriched GO Terms of Interacting Partners?
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