UTP18 and TLR8

		UTP18	TLR8
Description		UTP18 small subunit processome component	toll like receptor 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Membrane Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome	Golgi Membrane Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Endolysosome Membrane
	Molecular Function	RNA Binding	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding NAD+ Nucleosidase Activity Transmembrane Signaling Receptor Activity Signaling Receptor Activity Pattern Recognition Receptor Activity
	Biological Process	RRNA Processing	Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Immunoglobulin Mediated Immune Response Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 8 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus Cellular Response To Mechanical Stimulus
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade
Drugs			Imiquimod Resiquimod
Diseases
GWAS		Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Menarche (age at onset) ( 27182965) Metabolite levels ( 23823483)	Celiac disease ( 20190752)
Interacting Genes		10 interacting genes: CSNK2A1 ERBB2 HDAC5 KCNJ2 MBTD1 OGT PRDM1 RSAD1 TLR8 TXK	3 interacting genes: BTK MYD88 UTP18
Entrez ID		51096	51311
HPRD ID		10825	02296
Ensembl ID		ENSG00000011260	ENSG00000101916
Uniprot IDs		Q9Y5J1	Q9NR97
PDB IDs			3W3G 3W3J 3W3K 3W3L 3W3M 3W3N 3WN4 4QBZ 4QC0 4R07 4R08 4R09 4R0A 4R6A 5AWA 5AWB 5AWC 5AWD 5AZ5 5HDH 5WYX 5WYZ 5Z14 5Z15 6KYA 6TY5 6V9U 6WML 6ZJZ
Enriched GO Terms of Interacting Partners?
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