TIMMDC1 and IFNA2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TIMMDC1	IFNA2
Description		translocase of inner mitochondrial membrane domain containing 1	interferon alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding	Cytokine Activity Type I Interferon Receptor Binding Protein Binding
	Biological Process		Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Apoptotic Process Inflammatory Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway B Cell Differentiation Negative Regulation Of Interleukin-13 Production Negative Regulation Of Interleukin-5 Production Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Response To Exogenous DsRNA Negative Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Complex I biogenesis	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production
Drugs			Sifalimumab
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Primary biliary cholangitis ( 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33272962 28714469) Systemic sclerosis ( 31672989)	Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		70 interacting genes: AGR3 ANKRD46 APOC2 APOC4 APOL3 APP ARL6IP6 ATP6AP2 BCAP31 C14orf180 C3orf52 C4orf3 C5orf46 CCL4 CDS2 CMTM2 CREB3L1 CYP4F12 DCBLD2 DIABLO DRAM1 EPGN FAM20B FAM210B FATE1 FXYD3 GJB2 GPR151 GPR152 GPX8 HGS HSD17B13 IFNA2 KIR2DL4 LHFPL5 MARCHF5 MFSD14B MFSD5 NDUFB11 NINJ1 PEX5 PIGF PTPN1 PTPRN RNF24 SCAMP5 SCD SERF1A SERF1B SERP2 SLC35E4 SLC35F6 SMO ST6GAL2 STX12 STX6 TMEM144 TMEM14B TMEM176A TMEM199 TMEM203 TMEM239 TMEM31 TMEM54 TMEM65 TMEM86A TVP23B UNC93A YIF1A YIPF1	3 interacting genes: IFNAR1 IFNAR2 TIMMDC1
Entrez ID		51300	3440
HPRD ID		12817	00950
Ensembl ID		ENSG00000113845	ENSG00000188379
Uniprot IDs		C9JU35 Q9NPL8	P01563
PDB IDs			1ITF 1RH2 2HIE 2HYM 2KZ1 2LAG 2LMS 3S9D 3SE3 4YPG 4Z5R
Enriched GO Terms of Interacting Partners?
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