RNF181 and CARD11

Number of citations of the paper that reports this interaction (PubMedID 26711259)
13

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		RNF181	CARD11
Description		ring finger protein 181	caspase recruitment domain family member 11
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Immunological Synapse Cytoplasm Cytosol Plasma Membrane CBM Complex Membrane Raft Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Guanylate Kinase Activity Protein Binding Protein Self-association CARD Domain Binding
	Biological Process	Protein Ubiquitination Protein Autoubiquitination	I-kappaB Kinase/NF-kappaB Signaling B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production TORC1 Signaling B Cell Proliferation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Thymic T Cell Selection Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation GMP Metabolic Process GDP Metabolic Process Homeostasis Of Number Of Cells Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling
Drugs
Diseases
GWAS		Prostate cancer ( 21743467)	Asthma ( 34103634) Atopic dermatitis ( 23042114) Cadmium levels ( 26025379) Daytime sleep phenotypes ( 27126917) Dupuytren's disease ( 28886342) Intracranial aneurysm ( 29531279) Multiple sclerosis ( 31604244 24076602) Response to fenofibrate (total cholesterol levels) ( 27002377) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)
Interacting Genes		22 interacting genes: BCL10 BIRC2 BTG1 CARD11 CLK4 MRPS6 NPY5R PEG10 RBCK1 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U VPS11 ZMYND10	15 interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70
Entrez ID		51255	84433
HPRD ID		14236	06234
Ensembl ID		ENSG00000168894	ENSG00000198286
Uniprot IDs		Q9P0P0	A0A024R854 Q8TES3 Q9BXL7
PDB IDs			4JUP 4LWD
Enriched GO Terms of Interacting Partners?
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