CARD11 and SH2D3C

Number of citations of the paper that reports this interaction (PubMedID 16825666)
20

Data Source:
HPRD (in vivo)

		CARD11	SH2D3C
Description		caspase recruitment domain family member 11	SH2 domain containing 3C
Image
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane CBM Complex Membrane Raft Extracellular Exosome	Cytoplasm Axon Ruffle Membrane
	Molecular Function	Guanylate Kinase Activity Protein Binding Protein Self-association CARD Domain Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	I-kappaB Kinase/NF-kappaB Signaling B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production TORC1 Signaling B Cell Proliferation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Thymic T Cell Selection Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation GMP Metabolic Process GDP Metabolic Process Homeostasis Of Number Of Cells Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling
Drugs
Diseases
GWAS		Asthma ( 34103634) Atopic dermatitis ( 23042114) Cadmium levels ( 26025379) Daytime sleep phenotypes ( 27126917) Dupuytren's disease ( 28886342) Intracranial aneurysm ( 29531279) Multiple sclerosis ( 31604244 24076602) Response to fenofibrate (total cholesterol levels) ( 27002377) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)	Basophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		15 interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70	17 interacting genes: AR BCAR1 CARD11 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 GOLGA2 KIT MAPK1 MET NEDD9 PTK2B SNCAIP SRC
Entrez ID		84433	10044
HPRD ID		06234	05284
Ensembl ID		ENSG00000198286	ENSG00000095370
Uniprot IDs		A0A024R854 Q8TES3 Q9BXL7	B4DG32 Q8N5H7
PDB IDs		4JUP 4LWD	3T6G
Enriched GO Terms of Interacting Partners?
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