HERC5 and STK38

Number of citations of the paper that reports this interaction (PubMedID 16884686)
36

Data Source:
BioGRID (pull down)

		HERC5	STK38
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 5	serine/threonine kinase 38
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ISG15 Transferase Activity Ubiquitin Protein Ligase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Ubiquitination ISG15-protein Conjugation Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus	Cellular Protein Modification Process Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation	RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Pulmonary function decline ( 22424883) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Mean platelet volume ( 32888494) Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan) ( 28521775) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		15 interacting genes: BECN1 CCNA2 CCNB1 CCND1 CCNE1 CDKN1A ERCC2 IRF3 MTDH NME2 PITX2 STK38 UBE2D1 UBE2D2 UBE2L6	16 interacting genes: BANP CALM1 CTDP1 H2AC20 H2BC21 H3C6 HERC5 HRAS MOB2 S100B SENP2 TRAF3 TRIM14 TRIM25 YWHAB YWHAZ
Entrez ID		51191	11329
HPRD ID		10502	09511
Ensembl ID		ENSG00000138646	ENSG00000112079
Uniprot IDs		B4DXV3 Q9UII4	A0A024RD18 Q15208
PDB IDs			1PSB 6BXI
Enriched GO Terms of Interacting Partners?
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