CRBN and ZFP91

Number of citations of the paper that reports this interaction (PubMedID 30385546)
64

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CRBN	ZFP91
Description		cereblon	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Transmembrane Transporter Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Metal Ion Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Large Conductance Calcium-activated Potassium Channel Activity	Regulation Of Transcription By RNA Polymerase II Activation Of NF-kappaB-inducing Kinase Activity Protein K63-linked Ubiquitination
Pathways		Potential therapeutics for SARS
Drugs		Lenalidomide Thalidomide Pomalidomide
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)	Chronotype ( 30696823) HDL cholesterol levels ( 32203549) Medication use (calcium channel blockers) ( 31015401) Morning person ( 30696823) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		38 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CUL4B CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91	12 interacting genes: CDKN2A CEP70 CRBN FAM9A MAP3K14 PICK1 POU6F2 SRPK2 TP53BP2 TSPYL2 ZFP41 ZNF526
Entrez ID		51185	80829
HPRD ID		16750	11700
Ensembl ID		ENSG00000113851	ENSG00000186660
Uniprot IDs		Q96SW2	A0A024R4Z1 A0A024R4Z4 Q96JP5
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV	2M9A
Enriched GO Terms of Interacting Partners?
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