DYNC1LI1 and FBXL2

		DYNC1LI1	FBXL2
Description		dynein cytoplasmic 1 light intermediate chain 1	F-box and leucine rich repeat protein 2
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GO Annotations	Cellular Component	Kinetochore Spindle Pole Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Membrane Secretory Granule Membrane Ficolin-1-rich Granule Membrane	Cytoplasm Membrane SCF Ubiquitin Ligase Complex
	Molecular Function	RNA Binding Protein Binding ATP Binding GTP Binding GDP Binding Dynein Heavy Chain Binding	Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule-based Movement Cell Cycle Cell Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint	Cellular Protein Modification Process Proteolysis Protein Monoubiquitination Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modulation By Host Of Viral RNA Genome Replication
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
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Diseases
GWAS		Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Low density lipoprotein cholesterol levels ( 33339817)	Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Rostral anterior cingulate cortex volume ( 31530798)
Interacting Genes		14 interacting genes: BRCA2 CMTM6 CMTM7 FBXL2 GPD1L IKBKG NOP56 NUP85 OGT PGAM2 RAB4A REL SUSD5 TRIM71	12 interacting genes: APP AURKB CCND2 CDC34 COL7A1 DYNC1LI1 NLRP3 PIK3R2 SKP1 UBE2D1 UBE2D3 UBE2G1
Entrez ID		51143	25827
HPRD ID		10917	05736
Ensembl ID		ENSG00000144635	ENSG00000153558
Uniprot IDs		E9PHI6 Q9Y6G9	Q9UKC9
PDB IDs		6B9H 6PSD 6PSE	6O60
Enriched GO Terms of Interacting Partners?
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