FBXL2 and COL7A1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		FBXL2	COL7A1
Description		F-box and leucine rich repeat protein 2	collagen type VII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane SCF Ubiquitin Ligase Complex	Extracellular Region Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Calmodulin Binding Protein Phosphatase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Cellular Protein Modification Process Proteolysis Protein Monoubiquitination Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modulation By Host Of Viral RNA Genome Replication	Cell Adhesion Epidermis Development Negative Regulation Of Endopeptidase Activity Endodermal Cell Differentiation
Pathways			Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures COPII-mediated vesicle transport Integrin cell surface interactions Anchoring fibril formation Laminin interactions Laminin interactions Cargo concentration in the ER Collagen chain trimerization
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Rostral anterior cingulate cortex volume ( 31530798)	Age at first sexual intercourse ( 27089180) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Bone fracture in osteoporosis ( 28580392) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		12 interacting genes: APP AURKB CCND2 CDC34 COL7A1 DYNC1LI1 NLRP3 PIK3R2 SKP1 UBE2D1 UBE2D3 UBE2G1	16 interacting genes: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MIA3 MMP2 NPHP3 SHKBP1 THBS1 ZC3H7A
Entrez ID		25827	1294
HPRD ID		05736	00358
Ensembl ID		ENSG00000153558	ENSG00000114270
Uniprot IDs		Q9UKC9	Q02388 Q59F16
PDB IDs		6O60
Enriched GO Terms of Interacting Partners?
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