PC and MDH2

Number of citations of the paper that reports this interaction (PubMedID 8349677)
4

Data Source:
HPRD (in vitro)

		PC	MDH2
Description		pyruvate carboxylase	malate dehydrogenase 2
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome
	Molecular Function	Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Identical Protein Binding Metal Ion Binding	RNA Binding L-malate Dehydrogenase Activity Protein Self-association Malate Dehydrogenase (NADP+) Activity
	Biological Process	Pyruvate Metabolic Process Gluconeogenesis Lipid Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADH Metabolic Process Aerobic Respiration
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis	Gluconeogenesis Citric acid cycle (TCA cycle)
Drugs		Pyruvic acid Biotin 5-(hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-yl)pentanal	NADH Citric acid Xanthinol
Diseases
GWAS		Bipolar disorder ( 21926972 31043756) Body shape index ( 34021172) Familial squamous cell lung carcinoma ( 29924316) Hip circumference adjusted for BMI ( 34021172) HIV-1 susceptibility ( 22174851) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Coffee consumption ( 31959922)
Interacting Genes		6 interacting genes: GOT1 GOT2 MDH2 MYO7A PCBP2 SERPINH1	9 interacting genes: CRYAB CS FH GOT2 HSPB1 NDUFS1 PC SHANK3 WARS1
Entrez ID		5091	4191
HPRD ID		02032	01099
Ensembl ID		ENSG00000173599	ENSG00000146701
Uniprot IDs		A0A024R5C5 P11498	A0A024R4K3 B3KTM1 G3XAL0 P40926
PDB IDs		3BG3 3BG9	2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV
Enriched GO Terms of Interacting Partners?
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