NSDHL and RHBDD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NSDHL	RHBDD1
Description		NAD(P) dependent steroid dehydrogenase-like	rhomboid domain containing 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	C-3 Sterol Dehydrogenase (C-4 Sterol Decarboxylase) Activity 3-beta-hydroxy-delta5-steroid Dehydrogenase Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) Activity 3-beta-hydroxysteroid Dehydrogenase/C4-decarboxylase Activity 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) Activity 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) Activity	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Hair Follicle Development Cholesterol Biosynthetic Process Smoothened Signaling Pathway Cholesterol Metabolic Process Labyrinthine Layer Blood Vessel Development	Apoptotic Process Positive Regulation Of Protein Processing Membrane Protein Intracellular Domain Proteolysis Cellular Response To Unfolded Protein Cellular Response To UV ERAD Pathway Negative Regulation Of Apoptotic Process Post-translational Protein Modification Spermatid Differentiation Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Regulation Of Male Germ Cell Proliferation
Pathways		Cholesterol biosynthesis
Drugs		NADH
Diseases
GWAS		Glycated hemoglobin levels ( 34059833)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Kawasaki disease ( 33692975) Pulmonary function ( 17903307)
Interacting Genes		5 interacting genes: DCC GPR35 RHBDD1 TMEM31 TMX2	19 interacting genes: CGRRF1 CMTM5 CREB3L1 CTSA DAPK1 FBXO25 GYPC LPCAT2 LRRK2 MFHAS1 NSDHL PLEKHB2 RNF5 SEC22B SLC66A2 TGFA TMEM42 TMEM86B TMIE
Entrez ID		50814	84236
HPRD ID		02229	13206
Ensembl ID		ENSG00000147383	ENSG00000144468
Uniprot IDs		A0A384NPZ7 Q15738	Q8TEB9
PDB IDs		6JKG 6JKH	5EPP
Enriched GO Terms of Interacting Partners?
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