PAX5 and NEIL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PAX5	NEIL2
Description		paired box 5	nei like DNA glycosylase 2
Image
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle Mitotic Spindle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Microtubule Binding Zinc Ion Binding DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Humoral Immune Response Multicellular Organism Development Spermatogenesis Aging Animal Organ Morphogenesis Lateral Ventricle Development Cerebral Cortex Development Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Negative Regulation Of Histone H3-K9 Methylation	Base-excision Repair Depyrimidination
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs			Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Adult body size ( 32376654) Alzheimer's disease ( 30636644) Bipolar disorder ( 33169155) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) ghrelin levels ( 33852427) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)	Alcohol dependence ( 23942779) Apolipoprotein A1 levels ( 32203549) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Medication use (calcium channel blockers) ( 31015401) Neutrophil count ( 21507922) Nicotine use ( 23942779) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Systolic blood pressure ( 32902719) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		55 interacting genes: ACOT12 BCAS2 C1orf109 CCL19 CCNC CDK3 CIB3 CKS1B CREBBP CSNK2A1 CXorf38 DAXX DTX2 EBF1 ETS1 FBLN1 GNG13 GRHL2 HGS HMBOX1 HMGB3 HOXC8 ID2 ID3 KLHL38 KPNA1 KPNA2 KRTAP10-8 KRTAP9-3 LARP4 LDLRAP1 LONRF1 MAPK1 MAPK9 MYB NEIL2 NFYC NGLY1 OSGIN1 PNMA5 RAD52 RB1 RNF144B RUNX1 SAE1 SEC14L4 STAC TBP TLE4 TLK2 UBE2I UBE3A UBXN2B UBXN7 ZMYM5	10 interacting genes: CDHR3 CRX EP300 HOMEZ INCA1 LCN2 MEOX1 PAX5 REL TRIM27
Entrez ID		5079	252969
HPRD ID		01334	16406
Ensembl ID		ENSG00000196092	ENSG00000154328
Uniprot IDs		C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548	A0A024R361 Q969S2
PDB IDs		1K78 1MDM	1VZP
Enriched GO Terms of Interacting Partners?
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