NEIL2 and CDHR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NEIL2	CDHR3
Description		nei like DNA glycosylase 2	cadherin related family member 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle Mitotic Spindle	Plasma Membrane Adherens Junction Integral Component Of Membrane Catenin Complex
	Molecular Function	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Microtubule Binding Zinc Ion Binding DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Virus Receptor Activity Calcium Ion Binding Protein Binding Cadherin Binding
	Biological Process	Base-excision Repair Depyrimidination	Cell Morphogenesis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Multicellular Organism Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Viral Entry Into Host Cell Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs		Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Alcohol dependence ( 23942779) Apolipoprotein A1 levels ( 32203549) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Medication use (calcium channel blockers) ( 31015401) Neutrophil count ( 21507922) Nicotine use ( 23942779) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Systolic blood pressure ( 32902719) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 27182965) Asthma (childhood onset) ( 24241537) Childhood asthma with severe exacerbations ( 33328473) Childhood ear infection ( 27182965 28928442) Multiple sclerosis ( 31604244) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Smoking cessation in chronic obstructive pulmonary disease ( 29631575)
Interacting Genes		10 interacting genes: CDHR3 CRX EP300 HOMEZ INCA1 LCN2 MEOX1 PAX5 REL TRIM27	3 interacting genes: CXorf38 NEIL2 PARVG
Entrez ID		252969	222256
HPRD ID		16406	08042
Ensembl ID		ENSG00000154328	ENSG00000128536
Uniprot IDs		A0A024R361 Q969S2	B7Z8X2 E7EQG5 Q6ZTQ4
PDB IDs		1VZP	6PPO 6PSF 7KNV
Enriched GO Terms of Interacting Partners?
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