PAX4 and NRXN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PAX4	NRXN3
Description		paired box 4	neurexin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Cell Differentiation Pancreas Development Anatomical Structure Development	Neuron Cell-cell Adhesion Axon Guidance Learning Adult Behavior Social Behavior Vocalization Behavior
Pathways			Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Fruit consumption ( 32066663) Left-handedness ( 32989287) Metabolite levels ( 23823483) Nonsyndromic cleft palate ( 31609978) Type 2 diabetes ( 32794382 29632382 26818947 32499647 22158537 30718926 23532257) Type 2 diabetes (adjusted for BMI) ( 29632382)	Adiponectin levels ( 33562295) Adult body size ( 32376654) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 26865924 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Bone mineral density (hip) ( 30172743) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Daytime nap ( 33568662) Electrodermal activity ( 25387706) Figural/spatial cognitive ability ( 31620175) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 25673412) JT interval (sulfonylurea treatment interaction) ( 27958378) Medial orbital frontal cortex volume ( 31530798) Normal facial asymmetry (angle of deformation score) ( 30631343) Obesity ( 23563607 21552555) Objective response to lithium treatment in bipolar disorder ( 26503763) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Postherpetic neuralgia ( 33685280) Proliferative diabetic retinopathy in type 2 diabetes ( 29739359) Response to antidepressants (symptom improvement) ( 29160301) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Smoking initiation ( 33082346) Tea consumption ( 31046077) TPE interval (recovery after exercise) ( 32386560) Type 2 diabetes ( 28566273 30054458 30297969) Underweight status ( 25133637) Urinary sodium excretion ( 31409800) Waist circumference ( 19557197 25673412) Waist-hip ratio ( 25673412) Walking pace ( 33128006) Weight ( 28552196)
Interacting Genes		14 interacting genes: AURKA CABP5 EIF4A3 FBXO2 GMCL1 NAIF1 NECAB1 NFYC NME7 NRXN3 NTM NUTF2 PSMC1 UBL5	8 interacting genes: AFDN CASK DNAJC5 HTR6 NLGN1 NLGN2 NLGN3 PAX4
Entrez ID		5078	9369
HPRD ID		01333	08989
Ensembl ID		ENSG00000106331	ENSG00000021645
Uniprot IDs			A0A0A0MR89 A0A0U1RRJ0 Q9HDB5 Q9Y4C0
PDB IDs
Enriched GO Terms of Interacting Partners?
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