PAX4 and NFYC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PAX4	NFYC
Description		paired box 4	nuclear transcription factor Y subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Cell Differentiation Pancreas Development Anatomical Structure Development	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Folding Positive Regulation Of Transcription By RNA Polymerase II
Pathways			PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Fruit consumption ( 32066663) Left-handedness ( 32989287) Metabolite levels ( 23823483) Nonsyndromic cleft palate ( 31609978) Type 2 diabetes ( 32794382 29632382 26818947 32499647 22158537 30718926 23532257) Type 2 diabetes (adjusted for BMI) ( 29632382)	Adult body size ( 32376654) Airway obstruction (FEV1/FVC<70%) in never smokers ( 30845926) Airway obstruction (FEV1/FVC<lower limit of normal) in never smokers ( 30845926) Depressive and manic episodes in bipolar disorder ( 26297903) Platelet count ( 21507922) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: AURKA CABP5 EIF4A3 FBXO2 GMCL1 NAIF1 NECAB1 NFYC NME7 NRXN3 NTM NUTF2 PSMC1 UBL5	69 interacting genes: ADGRF5 ADNP2 APOL4 ARID2 ATF6 ATF6B BDH2 BICRA BICRAL CEP76 CIART CIC CRX CSN2 CXorf38 DR1 DST ELF1 FAM168A GAPDH HGS HIVEP1 HSFY1 HSFY2 JAK1 JUN KLF11 KLF15 KLHDC7B LIN54 LMO4 MYC NFYA NFYB NUTM2F OSTF1 PAX4 PAX5 PAX6 POGZ POU3F2 POU6F1 POU6F2 PRR20A PRR20B PRR20C PRR20D PRR20E RAD52 SAE1 SMAD2 SMAD3 SMAP1 SNX2 SP1 SP2 SP4 SREBF2 STOX1 TAF11 TAF12 TAF6 TBP UBXN7 USF3 ZDHHC17 ZMYM6 ZNF34 ZSCAN1
Entrez ID		5078	4802
HPRD ID		01333	05633
Ensembl ID		ENSG00000106331	ENSG00000066136
Uniprot IDs			Q13952
PDB IDs			1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS
Enriched GO Terms of Interacting Partners?
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