PAK3 and ARHGEF6

Number of citations of the paper that reports this interaction (PubMedID 9659915)
255

Data Source:
HPRD (in vivo)

		PAK3	ARHGEF6
Description		p21 (RAC1) activated kinase 3	Rac/Cdc42 guanine nucleotide exchange factor 6
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Postsynaptic Density Glutamatergic Synapse	Cytosol Lamellipodium
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Small GTPase Binding Metal Ion Binding Protein Serine Kinase Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	MAPK Cascade Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Axonogenesis Positive Regulation Of Fibroblast Migration Dendrite Development Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Synapse Organization Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Organic Cyclic Compound Positive Regulation Of DNA Biosynthetic Process	Apoptotic Process JNK Cascade Lamellipodium Assembly Regulation Of Catalytic Activity
Pathways		Generation of second messenger molecules CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle	NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS			Breast cancer ( 29059683)
Interacting Genes		13 interacting genes: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 RHOJ SNCA SYN1	38 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 CDK6 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580
Entrez ID		5063	9459
HPRD ID		02142	02226
Ensembl ID		ENSG00000077264	ENSG00000129675
Uniprot IDs		B2RCU6 O75914	B7Z3C7 Q15052 Q8N4Q3
PDB IDs		6FD3	1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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