DEF6 and ARHGAP22

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DEF6	ARHGAP22
Description		DEF6 guanine nucleotide exchange factor	Rho GTPase activating protein 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Perinuclear Region Of Cytoplasm	Nucleus Cytosol Focal Adhesion Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Angiogenesis Signal Transduction Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Regulation Of Postsynapse Organization
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Height ( 18391951 33713608) Hip circumference adjusted for BMI ( 34021172) Lymphocyte counts ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33493351 28714469) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Conduct disorder ( 20585324) Daytime sleep phenotypes ( 27126917) Diabetic retinopathy ( 21310492) Macular thickness ( 30535121) Refractive error ( 32231278) Self-employment ( 23593239) Systolic blood pressure ( 31134134) Systolic blood pressure (education interaction) ( 31134134)
Interacting Genes		32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688	13 interacting genes: ALG11 CACNA1A CCNDBP1 CDC42 DEF6 FXR1 GPRIN2 IL1RAPL1 MAPK8 PTPN20 RAC1 RHOA ZNF488
Entrez ID		50619	58504
HPRD ID		10869	12476
Ensembl ID		ENSG00000023892	ENSG00000128805
Uniprot IDs		Q9H4E7	A0A2X0SFC0 Q7Z5H3
PDB IDs
Enriched GO Terms of Interacting Partners?
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