DEF6 and SLU7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DEF6	SLU7
Description		DEF6 guanine nucleotide exchange factor	SLU7 homolog, splicing factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Membrane Nuclear Speck Small Nuclear Ribonucleoprotein Complex Intracellular Membrane-bounded Organelle Catalytic Step 2 Spliceosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Second Spliceosomal Transesterification Activity Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding
	Biological Process	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Intracellular Protein Transport RNA Splicing Cellular Response To Heat
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Height ( 18391951 33713608) Hip circumference adjusted for BMI ( 34021172) Lymphocyte counts ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33493351 28714469) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Asthma ( 32296059) Common carotid intima-media thickness ( 29206233)
Interacting Genes		32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688	29 interacting genes: AIMP2 ARHGEF5 BAG2 CCDC85B CEP70 DEF6 FHL3 GOLGA2 GTF2I IKBKG JMJD6 KDM1A KRT40 LMNA LONRF1 LZTS2 MCC NFKBID NSD3 PCBP2 PIBF1 PPIG PPIL3 PRMT5 PRMT6 TEPSIN THAP1 ZBED8 ZCCHC10
Entrez ID		50619	10569
HPRD ID		10869	12074
Ensembl ID		ENSG00000023892	ENSG00000164609
Uniprot IDs		Q9H4E7	O95391
PDB IDs			5XJC 6ICZ 6QDV
Enriched GO Terms of Interacting Partners?
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