MINK1 and ACTA2

Number of citations of the paper that reports this interaction (PubMedID 15032605)
1

Data Source:
HPRD (two hybrid)

		MINK1	ACTA2
Description		misshapen like kinase 1	actin alpha 2, smooth muscle
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Postsynaptic Density Axon Dendrite Extracellular Exosome	Extracellular Space Cytoplasm Cytosol Dynactin Complex Lamellipodium Filopodium Smooth Muscle Contractile Fiber Protein-containing Complex Cell Body Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	ATP Binding Protein Kinase Binding
	Biological Process	MAPK Cascade Regulation Of Cell-matrix Adhesion Protein Phosphorylation JNK Cascade Chemical Synaptic Transmission Multicellular Organism Development Regulation Of Cell-cell Adhesion Microvillus Assembly Regulation Of Cell Migration Actin Cytoskeleton Reorganization Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Dendrite Morphogenesis Positive Regulation Of P38MAPK Cascade Regulation Of AMPA Receptor Activity	Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Glomerular Mesangial Cell Development Mesenchyme Migration
Pathways		Oxidative Stress Induced Senescence	Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription
Drugs		Fostamatinib	Phenethyl Isothiocyanate
Diseases
GWAS		Intracranial aneurysm ( 30823506) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Metabolite levels (lipid measures) ( 27005778) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) PR interval ( 32439900)	Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 23770605) Immunoglobulin A ( 20694011) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)
Interacting Genes		14 interacting genes: ABI1 ACTA2 CALM3 CASKIN1 KIFAP3 MAP1B NCK1 NEDD4L NEFM PKP4 SPTBN2 TUBA1B YWHAB YWHAZ	18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1
Entrez ID		50488	59
HPRD ID		11366	00031
Ensembl ID		ENSG00000141503	ENSG00000107796
Uniprot IDs		Q8N4C8	D2JYH4 P62736
PDB IDs
Enriched GO Terms of Interacting Partners?
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