ACTA2 and GC

Number of citations of the paper that reports this interaction (PubMedID 12119014)
13

Data Source:
HPRD (in vitro)

		ACTA2	GC
Description		actin alpha 2, smooth muscle	GC vitamin D binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Dynactin Complex Lamellipodium Filopodium Smooth Muscle Contractile Fiber Protein-containing Complex Cell Body Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Cytosol Lysosomal Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	ATP Binding Protein Kinase Binding	Actin Binding Vitamin D Binding Vitamin Transmembrane Transporter Activity Calcidiol Binding
	Biological Process	Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Glomerular Mesangial Cell Development Mesenchyme Migration	Transport Vitamin Transmembrane Transport Vitamin D Metabolic Process Vitamin Transport
Pathways		Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription	Vitamin D (calciferol) metabolism
Drugs		Phenethyl Isothiocyanate	Vitamin D
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 23770605) Immunoglobulin A ( 20694011) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)	Blood protein levels ( 29875488) Granulocyte count ( 27863252) Lymphocyte counts ( 32888494) Metabolite levels ( 22916037) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Neutrophil count ( 32888494 27863252) Non-alcoholic fatty liver disease histology (other) ( 23213074) Platelet count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum 25-Hydroxyvitamin D levels ( 33382404 29545823 29325163 31841498) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum vitamin D-binding protein levels ( 24740207) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 29343764 22673963 20418485 25208829) Vitamin D levels (dietary vitamin D intake interaction) ( 29343764) White blood cell count ( 32888494 27863252)
Interacting Genes		18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1	14 interacting genes: ACTA1 ACTA2 ACTC1 C3 CCND3 CDC73 CUBN GRB2 HSP90AA1 LRIF1 LRP2 PIK3R3 SERF2 SLC9A3R1
Entrez ID		59	2638
HPRD ID		00031	00749
Ensembl ID		ENSG00000107796	ENSG00000145321
Uniprot IDs		D2JYH4 P62736	P02774
PDB IDs			1J78 1J7E 1KW2 1KXP 1LOT 1MA9
Enriched GO Terms of Interacting Partners?
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