P2RX4 and USP16

		P2RX4	USP16
Description		purinergic receptor P2X 4	ubiquitin specific peptidase 16
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Membrane Cell Junction Neuronal Cell Body Terminal Bouton Dendritic Spine Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Signaling Receptor Binding Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Ligand-gated Calcium Channel Activity	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Zinc Ion Binding Histone Binding Ubiquitin Binding
	Biological Process	Tissue Homeostasis Regulation Of Sodium Ion Transport Response To Ischemia Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Hypertrophy Neuronal Action Potential Sensory Perception Of Pain Calcium-mediated Signaling Positive Regulation Of Prostaglandin Secretion Response To ATP Ion Transmembrane Transport Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Endothelial Cell Activation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Pain Response To Axon Injury Positive Regulation Of Calcium-mediated Signaling Regulation Of Chemotaxis Sensory Perception Of Touch Positive Regulation Of Protein Kinase B Signaling Membrane Depolarization Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To Zinc Ion Cellular Response To ATP Apoptotic Signaling Pathway Regulation Of Ruffle Assembly Microglial Cell Migration Positive Regulation Of Microglial Cell Migration Positive Regulation Of Endothelial Cell Chemotaxis	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Histone Deubiquitination Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Histone H2A K63-linked Deubiquitination Mitotic Nuclear Division
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis Purinergic signaling in leishmaniasis infection	Ub-specific processing proteases
Drugs		Promethazine Eslicarbazepine acetate Eslicarbazepine
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Left ventricular obstructive tract defect (inherited effect) ( 28468790)
Interacting Genes		10 interacting genes: CDH5 DNAAF6 KRTAP1-1 KRTAP12-3 KRTAP5-9 MCM2 NBPF19 NOTCH2NLA USP16 WNT4	23 interacting genes: ANAPC2 BTF3 CALM1 CCT8 CDK1 EXOSC10 FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4-16 LTN1 OR8G1 P2RX4 PLK1 PTOV1 SGIP1 SLC34A3 TTK UBC UBD
Entrez ID		5025	10600
HPRD ID		09017	06881
Ensembl ID		ENSG00000135124	ENSG00000156256
Uniprot IDs		Q99571	Q9Y5T5
PDB IDs			2I50
Enriched GO Terms of Interacting Partners?
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