USP16 and ANAPC2

		USP16	ANAPC2
Description		ubiquitin specific peptidase 16	anaphase promoting complex subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Zinc Ion Binding Histone Binding Ubiquitin Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Histone Deubiquitination Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Histone H2A K63-linked Deubiquitination Mitotic Nuclear Division	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Negative Regulation Of Gene Expression Positive Regulation Of Synaptic Plasticity Positive Regulation Of Axon Extension Positive Regulation Of Dendrite Morphogenesis Cell Division Protein K11-linked Ubiquitination Positive Regulation Of Synapse Maturation
Pathways		Ub-specific processing proteases	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Eosinophil percentage of white cells ( 32888494)
Interacting Genes		23 interacting genes: ANAPC2 BTF3 CALM1 CCT8 CDK1 EXOSC10 FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4-16 LTN1 OR8G1 P2RX4 PLK1 PTOV1 SGIP1 SLC34A3 TTK UBC UBD	17 interacting genes: ANAPC11 ANAPC7 CDC20 CDC26 CDC27 FZR1 MAD2L1 MEOX1 PTTG1 SMAD2 SUMO2 UBC UBE2C UBE2D2 UFD1 USP16 WDR5
Entrez ID		10600	29882
HPRD ID		06881	07367
Ensembl ID		ENSG00000156256	ENSG00000176248
Uniprot IDs		Q9Y5T5	Q9UJX6
PDB IDs		2I50	4UI9 4YII 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6NXK 6OB1 6Q6G 6Q6H 6TLJ 6TM5 6TNT
Enriched GO Terms of Interacting Partners?
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