OAS2 and FBXO17

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		OAS2	FBXO17
Description		2'-5'-oligoadenylate synthetase 2	F-box protein 17
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process RNA Catabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity Interleukin-27-mediated Signaling Pathway Regulation Of Lactation	Glycoprotein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult asthma ( 27611488) Body mass index ( 26426971) Coffee consumption ( 29367735) Low HDL-cholesterol levels ( 31006500) Response to fenofibrate (adiponectin levels) ( 23149075) Retinitis pigmentosa ( 33514863) Thalamus volume ( 31530798) Visceral adipose tissue adjusted for BMI ( 22589738)	SAPHO syndrome ( 33816493)
Interacting Genes		3 interacting genes: APP CLK3 FBXO17	22 interacting genes: ADAMTSL4 ADRB2 CBY2 CDCA8 DZIP3 EIF4H JRK KPRP KRT75 KRTAP13-2 LASP1 OAS2 PTPN21 RAB11FIP2 RUNX1 SAXO1 SAXO2 SKP1 USP54 ZNF213 ZNF829 ZSCAN9
Entrez ID		4939	115290
HPRD ID		04518	16436
Ensembl ID		ENSG00000111335	ENSG00000269190
Uniprot IDs		P29728 Q7Z6D0	Q96EF6
PDB IDs
Enriched GO Terms of Interacting Partners?
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