ACR and ZP3

Number of citations of the paper that reports this interaction (PubMedID 11739644)
10

Data Source:
HPRD (in vitro)

		ACR	ZP3
Description		acrosin	zona pellucida glycoprotein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Golgi-associated Vesicle Protein-containing Complex Acrosomal Matrix	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Matrix Egg Coat Collagen-containing Extracellular Matrix
	Molecular Function	Protease Binding DNA Binding Amidase Activity Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding Mannose Binding Serine-type Peptidase Activity Zinc Ion Binding Fucose Binding	Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Binding Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding Receptor Ligand Activity
	Biological Process	Acrosome Matrix Dispersal Activation Of Adenylate Cyclase Activity Single Fertilization Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Response To Steroid Hormone	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Signal Transduction Binding Of Sperm To Zona Pellucida Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Egg Coat Formation Positive Regulation Of T Cell Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth
Pathways		Acrosome Reaction and Sperm:Oocyte Membrane Binding	Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS			Parkinson disease and lewy body pathology ( 25663231)
Interacting Genes		3 interacting genes: SERPINA5 ZP2 ZP3	11 interacting genes: ACR CLDN11 ENGASE FURIN MALL MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L
Entrez ID		49	7784
HPRD ID		06342	01690
Ensembl ID		ENSG00000100312	ENSG00000188372
Uniprot IDs		P10323	P21754
PDB IDs
Enriched GO Terms of Interacting Partners?
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