CNOT4 and KDM5C

Number of citations of the paper that reports this interaction (PubMedID 19346402)
62

Data Source:
BioGRID (enzymatic study)

		CNOT4	KDM5C
Description		CCR4-NOT transcription complex subunit 4	lysine demethylase 5C
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GO Annotations	Cellular Component	Nucleus Cytosol CCR4-NOT Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	DNA Binding Protein Binding Zinc Ion Binding Histone Demethylase Activity Histone H3-methyl-lysine-4 Demethylase Activity Histone H3-tri/di/monomethyl-lysine-4 Demethylase Activity Dioxygenase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Megakaryocyte Differentiation Protein Autoubiquitination	Chromatin Remodeling Response To Toxic Substance Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Negative Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	HDMs demethylate histones
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Clostridioides difficle infection ( 33841421) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Meat-related diet ( 32066663) Numerical cognitive ability ( 31620175)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		18 interacting genes: CNOT1 CNOT2 CNOT3 CNOT6 CNOT8 EP300 IL36RN KDM5C RBM15 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W	4 interacting genes: CALM1 CNOT4 H3C15 SUMO2
Entrez ID		4850	8242
HPRD ID		05369	02442
Ensembl ID		ENSG00000080802	ENSG00000126012
Uniprot IDs		A0A024R776 A0A024R781 A0A024R785 O95628	A0A6M4C8G8 P41229
PDB IDs		1E4U 1UR6	2JRZ 5FWJ
Enriched GO Terms of Interacting Partners?
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