NEDD9 and RAPGEF1

Number of citations of the paper that reports this interaction (PubMedID 9497377)
20

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		NEDD9	RAPGEF1
Description		neural precursor cell expressed, developmentally down-regulated 9	Rap guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Cytosol Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium	Cytoplasm Early Endosome Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Protein Tyrosine Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Cytoskeleton Organization Cell Cycle Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Regulation Of Growth Actin Filament Bundle Assembly Cell Division Positive Regulation Of Protein Tyrosine Kinase Activity Actin Filament Reorganization Activation Of GTPase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Positive Regulation Of Neuron Projection Development Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Establishment Of Endothelial Barrier Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus
Pathways			Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 RAC3 GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs
Diseases
GWAS		Childhood dental caries in permanent teeth ( 29931343) Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) HIV-1 susceptibility ( 22174851) Macular thickness ( 30535121) Prostate cancer ( 25217961) Small cell lung carcinoma ( 28604730)	Cerebrospinal fluid Î±-synuclein levels ( 29959729) Cutaneous malignant melanoma ( 32341527) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Kidney volume ( 34128465) Nevus count or cutaneous melanoma ( 32341527) Optic disc size ( 31809533)
Interacting Genes		71 interacting genes: ABL1 ANKS1A APP AURKA BANP BCAR1 BCAR3 C19orf54 CDC42EP2 CDH1 CHAT CRK CRKL DIMT1 DMRTB1 DOCK9 DPPA4 ELSPBP1 EXOSC8 FAM102A FAM168B FOSB FYN FZR1 HOXA1 ID2 INCA1 IRF4 ITCH KLHL20 KRT32 LCK LHX8 LYN MED19 MICAL1 NAB2 NBPF19 NCK1 NFKBIA NOTCH2NLA NOTCH3 PIK3CA PIK3R3 PRAM1 PRR20A PTK2 PTK2B PTPN11 PTPN12 PXN RAPGEF1 RBPMS REL RFX6 SH2D3C SMAD1 SMAD2 SMAD3 SNAPIN TBX19 TCF3 TFCP2 TRAF2 TRIM23 TRIM27 TRIP6 WWOX ZNF318 ZNF76 ZYX	20 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 PDGFRA RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1
Entrez ID		4739	2889
HPRD ID		11888	02627
Ensembl ID		ENSG00000111859	ENSG00000107263
Uniprot IDs		A0A024QZV9 A0A087WUD2 Q14511	Q13905
PDB IDs		2L81 5X3S	5L23
Enriched GO Terms of Interacting Partners?
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