PPP1R12A and MPRIP

Number of citations of the paper that reports this interaction (PubMedID 15545284)
29

Data Source:
HPRD (two hybrid, in vivo)

		PPP1R12A	MPRIP
Description		protein phosphatase 1 regulatory subunit 12A	myosin phosphatase Rho interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc A Band Contractile Fiber PTW/PP1 Phosphatase Complex	Cytosol Focal Adhesion Actin Cytoskeleton
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding	Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Mitotic Cell Cycle Protein Dephosphorylation Centrosome Cycle Signal Transduction Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation Of Myosin-light-chain-phosphatase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Cellular Response To Xenobiotic Stimulus Regulation Of Establishment Of Endothelial Barrier	Actin Filament Organization
Pathways		Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Platelet count ( 32888494) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Diabetic retinopathy ( 21441570) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Hemoglobin ( 32888494) Obesity-related traits ( 23251661)
Interacting Genes		14 interacting genes: ATXN10 CDKN3 DMPK IL16 ILF3 ILK KDM1A MPRIP PRKG1 RHOA ROCK1 ROCK2 SETD7 YWHAG	16 interacting genes: ATXN7 COL6A1 IKBKG LSM8 NOS3 PIAS4 PPP1R12A PPP1R12C PTEN RACGAP1 RHOA SMARCA2 YTHDC1 YWHAB YWHAG YWHAQ
Entrez ID		4659	23164
HPRD ID		03606	17591
Ensembl ID		ENSG00000058272	ENSG00000133030
Uniprot IDs		B2RAH5 O14974	Q6WCQ1 Q8N236
PDB IDs		2KJY 5HUZ
Enriched GO Terms of Interacting Partners?
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