MGMT and UBA1

Number of citations of the paper that reports this interaction (PubMedID 8573590)
56

Data Source:
HPRD (in vitro, in vivo)

		MGMT	UBA1
Description		O-6-methylguanine-DNA methyltransferase	ubiquitin like modifier activating enzyme 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	DNA Binding Methylated-DNA-[protein]-cysteine S-methyltransferase Activity Calcium Ion Binding Methyltransferase Activity DNA-methyltransferase Activity	RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding
	Biological Process	DNA Ligation DNA Repair DNA Methylation DNA Dealkylation Involved In DNA Repair Response To Xenobiotic Stimulus Response To Toxic Substance Cellular Response To Oxidative Stress Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Response To Folic Acid Mammary Gland Epithelial Cell Differentiation Cellular Response To Organic Cyclic Compound Cellular Response To Ionizing Radiation Positive Regulation Of Double-strand Break Repair	Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein Modification By Small Protein Conjugation
Pathways		MGMT-mediated DNA damage reversal	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Cysteine Zinc S-Methylcysteine S-Benzylcysteine Dinitrochlorobenzene Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Hexatantalum Dodecabromide Quercetin
Diseases
GWAS		Adult body size ( 32376654) Alzheimer's disease in APOE e4- carriers ( 25778476) Anorexia nervosa ( 31308545) Chronotype ( 30696823) Drug experimentation measurement ( 30718321) Gut microbiota (functional units) ( 27694959) Hand grip strength ( 29691431 29313844) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Lead levels ( 26025379) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) MGMT methylation in smokers ( 26183928) Modic changes ( 30808802) Response to temozolomide ( 23047291) Tea consumption ( 31046077) Triglyceride levels in HIV infection ( 33109212) Waist-to-hip circumference ratio (ever vs never smoking interaction) ( 23192594)
Interacting Genes		10 interacting genes: CREBBP CSNK2A1 CSNK2A2 EP300 ESR1 FGFR2 PCNA PRKACA PRKCA UBA1	52 interacting genes: ABCF1 BUB3 CDC34 CDK1 CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A OGT PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2
Entrez ID		4255	7317
HPRD ID		01135	02440
Ensembl ID		ENSG00000170430	ENSG00000130985
Uniprot IDs		B4DEE8 P16455	A0A024R1A3 P22314
PDB IDs		1EH6 1EH7 1EH8 1QNT 1T38 1T39 1YFH	4P22 6DC6
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?