MEOX1 and NEIL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		MEOX1	NEIL2
Description		mesenchyme homeobox 1	nei like DNA glycosylase 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle Mitotic Spindle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Microtubule Binding Zinc Ion Binding DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Somite Specification Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Biological_process Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Somite Development Sclerotome Development	Base-excision Repair Depyrimidination
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs			Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Fractures ( 30158200)	Alcohol dependence ( 23942779) Apolipoprotein A1 levels ( 32203549) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Medication use (calcium channel blockers) ( 31015401) Neutrophil count ( 21507922) Nicotine use ( 23942779) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Systolic blood pressure ( 32902719) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		99 interacting genes: ACBD4 ACOT12 ALOX5 ANAPC2 APP APPL1 ATG9A BANP BNIP2 BYSL C14orf119 C1orf109 C1orf50 C2CD6 CACNB3 CCDC102B CCDC103 CDC34 CIAO1 CIB3 CKS1B CNOT11 CSNK2A1 CWF19L2 CYFIP1 DCX DUSP3 EIF4A3 EIF4EBP1 EMD FAM126B FMR1 GCC1 GEMIN2 GPANK1 GYS1 HMBOX1 HMGB3 HOMER3 HOXC8 INPP5J KANK2 KCTD7 L3MBTL2 LMNA MAPK9 MBD3 MCRS1 MEF2A MID1 MID2 MKRN3 MLX MORF4L1 MVP NAGK NDOR1 NEIL2 OSGIN1 PAGE3 PARVG PAX1 PAX3 PCP2 PDE4C PELI2 PIN1 PLCD4 PM20D2 POLR3GL PPM1F PRKAG1 PRKN QRICH1 RAD52 RANBP3 RBM41 RBM5 SDCBP SEC14L4 SOX10 SPAG8 SPIC SYT17 TCEANC TCP11L1 TEX33 TRAPPC2L TRIM41 TRIML2 TRIP10 TXLNA TXNL4B UBE2R2 UBXN2B UBXN7 UNC45A ZCCHC10 ZNF410	10 interacting genes: CDHR3 CRX EP300 HOMEZ INCA1 LCN2 MEOX1 PAX5 REL TRIM27
Entrez ID		4222	252969
HPRD ID		02537	16406
Ensembl ID		ENSG00000005102	ENSG00000154328
Uniprot IDs		P50221	A0A024R361 Q969S2
PDB IDs			1VZP
Enriched GO Terms of Interacting Partners?
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