MAP3K4 and GADD45B

Number of citations of the paper that reports this interaction (PubMedID 9827804)
210

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MAP3K4	GADD45B
Description		mitogen-activated protein kinase kinase kinase 4	growth arrest and DNA damage inducible beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm
	Molecular Function	MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	MAPK Cascade Placenta Development Protein Phosphorylation Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Telomerase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Telomere Capping	Negative Regulation Of Protein Kinase Activity Apoptotic Process Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of P38MAPK Cascade
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Aging ( 22773346) Blood protein levels ( 28240269) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)
Interacting Genes		27 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 EPHB4 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	16 interacting genes: CCNB1 CDK1 CDKN1A CNOT9 EFHC1 ESR1 GADD45G GADD45GIP1 MAP2K7 MAP3K4 MAP3K5 NFIX PCNA PPARA PPARD PPARG
Entrez ID		4216	4616
HPRD ID		03886	05382
Ensembl ID		ENSG00000085511	ENSG00000099860
Uniprot IDs		Q9P1M2 Q9Y6R4	K7EPQ8 O75293
PDB IDs
Enriched GO Terms of Interacting Partners?
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