MCM2 and GINS4

Number of citations of the paper that reports this interaction (PubMedID 22374673)
12

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		MCM2	GINS4
Description		minichromosome maintenance complex component 2	GINS complex subunit 4
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm MCM Complex CMG Complex	GINS Complex Nucleoplasm Cytoplasm CMG Complex
	Molecular Function	DNA Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding Histone Binding 3'-5' DNA Helicase Activity Metal Ion Binding	Protein Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Nucleosome Assembly Apoptotic Process Cellular Response To Interleukin-4 Cochlea Development Mitotic DNA Replication Initiation Negative Regulation Of DNA Helicase Activity	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA-dependent DNA Replication
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Unwinding of DNA Unwinding of DNA
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Red cell distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		58 interacting genes: AKAP8 APP ASF1A ATM ATR CCNB2 CCNC CD86 CDC45 CDC6 CDC7 CDK2 CDK4 CDK6 CDKN2A CDT1 CPSF1 CSNK2A1 DBF4 ELL EP300 ESCO2 FBXO7 GINS4 GNB5 GTF2B GTF2H1 H3-4 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHB PHC2 PLK1 PTEN RAD52 RPA1 RPA2 RPA3 RPS4X SIK1 TBP TCEA2 TERF1 TERF2IP	18 interacting genes: - BIN3 CDC45 CTNNBIP1 DMAP1 GINS1 GINS2 GINS3 IDO2 KIF16B LHX8 MCM2 PBX4 POLA1 POLD1 POLE PPP1R13B SIK1
Entrez ID		4171	84296
HPRD ID		00303	11583
Ensembl ID		ENSG00000073111	ENSG00000147536
Uniprot IDs		P49736	Q9BRT9
PDB IDs		4UUZ 5BNV 5BNX 5BO0 5C3I 5JA4 6XTX 6XTY 6YA7	2E9X 2EHO 2Q9Q 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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