MCF2 and RHOG

Number of citations of the paper that reports this interaction (PubMedID 12376551)
57

Data Source:
HPRD (in vitro)

		MCF2	RHOG
Description		MCF.2 cell line derived transforming sequence	ras homolog family member G
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Membrane	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Dendrite Development Intracellular Signal Transduction Negative Regulation Of Axonogenesis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Leukemia Inhibitory Factor	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Engulfment Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Cell Chemotaxis Activation Of GTPase Activity Regulation Of Ruffle Assembly Regulation Of Neutrophil Migration Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Plateletcrit ( 32888494)
Interacting Genes		9 interacting genes: ERCC3 GNA13 GNB1 RAC1 RHOA RHOG SHANK2 STUB1 TNK2	21 interacting genes: ARHGDIA ARHGDIG CCR2 DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 ERCC6 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3
Entrez ID		4168	391
HPRD ID		02406	01537
Ensembl ID		ENSG00000101977	ENSG00000177105
Uniprot IDs		B2R9S6 P10911	P84095 Q6ICQ8
PDB IDs			6UKA
Enriched GO Terms of Interacting Partners?
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