MC1R and MC4R

Number of citations of the paper that reports this interaction (PubMedID 12165561)
66

Data Source:
HPRD (in vivo, in vitro)

		MC1R	MC4R
Description		melanocortin 1 receptor	melanocortin 4 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Ubiquitin Protein Ligase Binding	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development UV Protection Positive Regulation Of Protein Kinase A Signaling Regulation Of Metabolic Process Sensory Perception Of Pain Negative Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Melanin Biosynthetic Process Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Kinase B Signaling UV-damage Excision Repair Positive Regulation Of Protein Kinase C Signaling	Diet Induced Thermogenesis Energy Reserve Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Regulation Of Metabolic Process Positive Regulation Of Bone Resorption Regulation Of Eating Behavior Response To Melanocyte-stimulating Hormone Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Afamelanotide CZEN 002 Bremelanotide	Bremelanotide Setmelanotide
Diseases
GWAS		Basal cell carcinoma ( 21700618 31174203 27539887) Black vs. non-black hair color ( 26184321) Black vs. red hair color ( 18483556) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 27424798) Facial pigmentation ( 25705849) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627 29662168) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Melanoma ( 21983787 28212542 24980573 19578364) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527 30429480) Non-melanoma skin cancer ( 23548203 29739929) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Perceived skin darkness ( 25963972) Red vs non-red hair color ( 17952075 26184321) Red vs. brown/black hair color ( 30531825) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 17952075 25963972) Squamous cell carcinoma ( 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 27723757 22561518) Youthful appearance (self-reported) ( 32339537)	Adult body size ( 32376654) Antipsychotic drug-induced weight gain ( 22566560) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat percentage ( 26833246) Body mass index ( 28552196 29381148 24064335 23563607 26426971 19079260 19079261 26961502 24348519 23669352 24861553 18454148 31453325 28892062 25673413 20935630 29273807 28448500 25953783) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age interaction) ( 25953783) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) C-reactive protein levels ( 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Childhood body mass index ( 33045005 26604143) Childhood onset type 2 diabetes ( 33479058) Cobalt levels ( 26025379) Coffee consumption ( 31046077) Coffee consumption (cups per day) ( 31837886) Coronary artery disease ( 26343387 33020668) Daytime sleep phenotypes ( 27126917) Dentures ( 31235808) Diastolic blood pressure ( 27841878) Fat body mass ( 24064335) Fatty acid desaturase activity (serum) ( 30453627) Femoral neck bone mineral density ( 30172743) Free thyroxine concentration ( 30367059) Fruit consumption ( 32066663) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 31562340) Hip circumference ( 28552196 31453325 25673412) Hip circumference variance ( 31453325) Leg fat mass and leg lean mass (pleiotropy) ( 32719433) Leg lean mass (fat adjusted) ( 32719433) Metabolic syndrome ( 31589552) Myocardial infarction ( 33532862) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obese vs. thin ( 30677029) Obesity ( 23563607 19151714) Obesity (early onset extreme) ( 20421936 23563609) Obesity (extreme) ( 30677029) Obesity-related traits ( 22013104) Systolic blood pressure ( 30224653) Total body bone mineral density ( 30172743) Triglyceride levels ( 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 22885922 24509480 30054458 30297969 32499647 30718926 28869590) Ulna and radius bone mineral density ( 30172743) Urate levels ( 31578528 23263486) Waist circumference ( 28552196 19557197 31453325 25673412) Waist circumference and related phenotypes ( 18454146) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412) Weight ( 19079260)
Interacting Genes		4 interacting genes: ASIP ICAM1 MC4R POMC	20 interacting genes: AGRP AIG1 ASIP ATP6V0E2 ATRNL1 CD81 GRK2 IL1RAP MAL MC1R NPC1 NPY PDIA6 PLLP POMC PRKACA TMEM19 TMEM94 TSPAN3 YIPF3
Entrez ID		4157	4160
HPRD ID		01118	01116
Ensembl ID		ENSG00000258839	ENSG00000166603
Uniprot IDs		Q01726 Q1JUL4	P32245
PDB IDs			2IQP 2IQR 2IQS 2IQU 2IQV 2IQW 6W25
Enriched GO Terms of Interacting Partners?
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